Gonzalez fouled off a pitch and grabbed his right wrist after his swing. He crouched near the Rockies' dugout while being attended to by a trainer and manager Jim Tracy. He was replaced by Ryan Spilborghs.
Gonzalez was taken to a local hospital to have an MRI performed on his wrist, a Rockies spokesperson said.
Gonzalez missed eight games earlier this month after suffering a deep bone bruise on his right wrist when he crashed into the outfield wall making a catch against the Kansas City Royals on July 3.
Gonzalez homered in his first at-bat Thursday.