Manager Manny Acta said Saturday that Santana would probably wind up there because of a mild concussion. Acta also said shortstop Asdrubal Cabrera is day to day because of tightness in his left hamstring. Both players left Friday's game against the Chicago White Sox.
Cabrera hurt himself going after a ball and was replaced in the seventh inning, while Santana left in the eighth after being struck by a foul tip.
The injuries are a big blow to a team already missing Travis Hafner.
"I just don't think we have the depth of some clubs to absorb these type of injuries," Acta said. "We're not talking about a backup going down. We're talking about our three, four, five in our lineup. Last year was our whole outfield plus our designated hitter. That's not very likely to happen, but we have to deal with it. We have to fight. You can't throw your hands up and say, 'Here we go again.' You have to continue to fight."
Hafner had an MRI on Thursday on his right knee and took an anti-inflammatory for irritation in the meniscus. He did not travel to Chicago and will be re-evaluated Monday.
"He's going to do some activities and we'll make a decision on whether he's going to be able to play or not," Acta said.
Acta downplayed the possibility of surgery.
"It's obviously a consideration for everyone that is hurt," Acta said. "When he shows up on Monday, he's going to go through some tests and we'll make a decision, playing-wise."
Although the Indians were missing some key pieces, third baseman Jack Hannahan was back in the lineup Saturday. He had missed 11 games with lower back soreness.