The Rockies made the moves before Saturday night's game against San Francisco.
Cuddyer has been bothered in the last several days by a strained right oblique muscle. He is hitting .260 with 15 home runs and 56 RBIs.
Friedrich was scheduled to start Sunday, but is out with a stress fracture in his lower back. He is 5-8 with a 6.17 ERA.
The Rockies recalled infielder/outfielder Matt McBride and right-handed reliever Edgmer Escalona from Triple-A Colorado Springs.