The Orioles also optioned right-handed reliever Alex Burnett to Norfolk, placed outfielder Nolan Reimold on the 15-day disabled list with a right hamstring strain and recalled right-hander Jake Arrieta on Saturday.
Jurrjens was signed to a minor league deal in spring training. He went 4-1 with a 3.14 ERA in eight starts for Norfolk. He is 53-37 with a 3.62 ERA in 126 major league games.
To make room for Jurrjens on the 40-man roster, second baseman Brian Roberts was transferred to the 60-day disabled list.