Promotion officials announced the matchup on Tuesday. The bout will take place at UFC 190 at HSBC Arena in Rio de Janeiro.
Nogueira (34-9-1) has not fought since a vicious knockout loss in the first round of a bout against Roy Nelson last April. The 38-year-old has been limited to only three appearances in the last three years due to various injuries.
Since winning a UFC interim heavyweight title in February 2008, Nogueira has gone 3-5 and been finished in all five losses. Fighting out of Rio de Janeiro, he is closing in on 16 years of professional experience.
Struve (25-7) is looking to rebound from back-to-back knockout losses. He missed the majority of the last two years dealing with a bicuspid aortic valve -- a heart disorder that disrupts blood flow. His return from the condition was delayed in July, when he fainted in the locker room ahead of a scheduled fight against Matt Mitrione at UFC 175. He eventually returned in December and suffered a first-round knockout loss to Alistair Overeem.
A female bantamweight title fight between Ronda Rousey (11-0) and Bethe Correia (9-0) will headline UFC 190. In addition, Nogueira's twin brother, Antonio Rogerio Nogueira (21-6) is scheduled to fight Mauricio "Shogun" Rua (22-10).