Representatives for Holm (10-3) have drafted a written request to the New York State Athletic Commission that it review the job performed by referee Todd Anderson.
The request asks the commission to review Anderson's "failure to deduct one or more points from [de Randamie]" for throwing punches after the bell. It also asks the NYSAC to "determine an appropriate result" following its review.
A spokesperson for the NYSAC told ESPN.com it had not yet received the request, but Holm's representatives said it was filed via both email and U.S. mail on Wednesday.
MMAFighting.com first reported Holm's intent to appeal.
Holm suffered a unanimous decision loss to de Randamie in the main event of UFC 208 on Saturday. The five-round bout was for the UFC's inaugural female featherweight title.
Immediate controversy arose, as de Randamie (7-3) landed obvious punches after the bell on two occasions. In the second round, Holm was visibly wobbled by a right hand de Randamie threw after the bell. De Randamie landed another punch after the bell in the third round.
All three judges scoring the 145-pound title fight had it 48-47 for de Randamie, meaning had Anderson taken a point, the fight would have resulted in a draw. Anderson did not take a point in the contest, although he warned de Randamie for throwing late punches after the third round.
De Randamie apologized for the late shots immediately after the fight. She has since stated on social media she feels she "owes" Holm an immediate rematch.
Lenny Fresquez, Holm's longtime manager, told ESPN.com, "The next time Holly steps into the Octagon, I would like it to be for a title."