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Guide to UFC 216: Predictions, analysis and full coverage

Tony Ferguson and Kevin Lee will fight for the interim lightweight title at UFC 216. Brandon Magnus/Zuffa LLC/Getty Images

UFC 216, taking place at the T-Mobile Arena in Las Vegas on Oct. 7, is headlined by one of the most intriguing matchups of the year. Tony Ferguson, a winner of nine in a row -- most recently a unanimous decision victory against former champion Rafael dos Anjos -- takes on rising star Kevin Lee for the interim lightweight belt. Lee is coming off a dominant first round submission against Michael Chiesa and has had his hand raised in five consecutive.

Demetrious Johnson, arguably the best pound-for-pound fighter of all-time, will also look to set the record for most title defenses in a row with 11 against Ray Borg. This flyweight title fight was initially scheduled for UFC 215 in Edmonton, Alberta, Canada, but Borg got sick just days prior and it was rescheduled.

Fabricio Werdum takes on Derrick Lewis in a battle among heavyweights. Both are looking to rebound from tough losses, Werdum to Alistair Overeem and Lewis to Mark Hunt. Another top matchup to watch is the return of Paige VanZant, who has not fought since a submission loss to Michelle Waterson last December. She squares off with Jessica Eye, hoping to find winning ways again after three straight losses.

Who will come out on top?

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