Guide to UFC 225: Predictions, analysis and full coverage

Yoel Romero and Robbert Whittaker will square off for the second time, as they headline UFC 225 in Chicago. Kevork Djansezian/Zuffa LLC via Getty Images

You want a loaded card? You got it with UFC 225 in Chicago. From top to bottom, the matchups are among the most anticipated of the year. Headlining the night is a rematch between middleweight champion Robert Whittaker and Yoel Romero, which was slated to be a title bout until Romero failed to make weight on Friday. Whittaker is riding an eight-fight win streak. Romero is coming off a brutal KO win against Luke Rockhold in February (in which Romero also missed weight).

The co-main event features former UFC lightweight champion Rafael dos Anjos against Colby Covington in a battle for the interim welterweight title. Covington impressed most recently against BJJ specialist Demian Maia, and Dos Anjos has looked dominant since moving to this weight class last year. The winner is expected to face Tyron Woodley for the undisputed belt.

Other intriguing fights on the card include Holly Holm vs. Megan Anderson, Alistair Overeem vs. Curtis Blaydes, Claudia Gadelha vs. Carla Esparza, Joseph Benavidez vs. Sergio Pettis and the return of former WWE Superstar CM Punk, who takes on Mike Jackson.

Who will come out on top?

UFC 225 storylines

Yoel Romero misses weight; main event fight vs. Robert Whittaker in jeopardy for UFC 225

UFC 225 Cheat Sheet: Robert Whittaker vs. Yoel Romero II

A day with the Colby Covington, the villain of the UFC

UFC 225 Cheat Sheet: Rafael dos Anjos vs. Colby Covington

With court case behind him, CM Punk ready for UFC 225

The stats that will define Whittaker vs. Romero II at UFC 225

Who is Mike Jackson? A look at CM Punk's unlikely UFC 225 opponent

My life as a fighter: Rashad Evans

Megan Anderson ready for long-anticipated Octagon debut against Holly Holm at UFC 225

Robert Whittaker determined to become "best fighter ever"

UFC 225 undercard boasts major title implications

Megan Anderson ready for long-anticipated Octagon debut against Holly Holm

Whittaker-Romero rematch not ideal, but necessary

Ex-WWE star CM Punk to make second UFC appearance

Australian heavyweight Tai Tuivasa is a UFC prospect to keep an eye on

Holly Holm-Megan Anderson featherweight bout added to UFC 225

Now-healthy Benavidez sees UFC title shot next with win

Bout between Andrei Arlovski and Tai Tuivasa finalized for UFC 225

Rashad Evans fighting Anthony Smith at UFC 225