The pay-per-view event will take place Nov. 3 inside Madison Square Garden. The UFC has not yet announced a main event for the card.
These two middleweights met previously in a 185-pound title fight at UFC 194 in December 2015. Rockhold claimed the middleweight championship by defeating Weidman via TKO in the fourth round.
Rockhold (16-4), of San Jose, fought Yoel Romero for the interim title at UFC 221 earlier this year and came up short by knockout. He considered a move up to the 205-pound weight class but has apparently postponed that in favor of the Weidman rematch.
Fighting out of Long Island, New York, Weidman (14-3) hasn't fought since a submission win over Kelvin Gastelum in July 2017. He has been sidelined with a thumb injury since but remains in the thick of title contention at 185 pounds.