UFC officials announced the matchup Saturday. It will take place Dec. 10 at Air Canada Centre in Toronto.
It's the second time the promotion has booked this particular fight. The two were originally scheduled to meet in the main event of a UFC Fight Night event in March, but Ortiz pulled out due to injury.
Ortiz (16-9-1) ended up being paired with Ryan Bader at UFC 132 four months later. The former 205-pound champion saved his career in the fight, upsetting Bader with a submission win in the first round.
One month later, Ortiz accepted an opportunity to face Rashad Evans in the main event of UFC 133 on short notice. Evans won the fight by TKO.
Nogueira (19-5) will look to snap the first two-fight losing streak of his career. After looking impressive in a first-round TKO victory over Luiz Cane in his 2009 UFC debut, he's gone 1-2 since.
Brett Okamoto covers mixed martial arts for ESPN.com. Follow him on Twitter.