After suffering the first loss of his pro career in October 2011, a fourth-round knockout to then-lightweight champion Frankie Edgar, Maynard got back in the win column on June 22 with a split decision over Clay Guida.
Maynard has a professional record of 11-1-1 with one no-contest.
Lauzon could have put himself in the lightweight contender conversation Feb. 22 when he took on Anthony Pettis. But a head kick from Pettis in the first round knocked him out.
He rebounded from that loss on Aug. 4 with a third-round submission of Jamie Varner. Lauzon is 22-7 overall.
It will be the second bout between dos Santos and Velasquez in a little more than a year.
Dos Santos registered a first-round knockout of Velasquez in November 2011 to claim the heavyweight title belt.
The two met in a 205-pound bout on Sept. 6, 2003. Griffin submitted Sonnen in the first round.