UFC officials announced the pairing on Monday. ESPN.com currently ranks Pickett and Wineland at Nos. 6 and 8, respectively, in the 135-pound division.
Pickett (22-6) is coming off a first-round knockout performance over Yves Jabouin in September. The Brit is 2-1 in the UFC with back-to-back finishes to his credit. He submitted Damacio Page via rear naked choke in April.
Wineland (19-8-1) looks to build on the momentum of a second-round finish over Scott Jorgensen at a UFC on FX event in June. The Indiana native dropped his first two fights in the UFC to elite competitors Urijah Faber and Joseph Benavidez.
A former WEC champion in the weight class, Wineland had won four straight before the two-fight skid.