An undisclosed injury has forced Hieron's original opponent, Erick Silva, off the card. UFC officials announced the switch on Wednesday.
Woodley (10-1) is coming off the first loss of his career, a fourth-round TKO to Strikeforce welterweight champion Nate Marquardt. The former collegiate wrestler has posted notable decision wins over Tarec Saffiedine and Paul Daley.
He'll face another fighter looking for his first UFC win in Hieron (23-6). The veteran mixed martial artist is 0-3 all-time in the Octagon. His latest loss came via unanimous decision against Jake Ellenberger in October.
Silva (14-3) misses an opportunitiy to rebound from an October loss to Jon Fitch at UFC 153. The Brazilian is considered one of the brightest prospects at 170 pounds, with two first-round knockout victories in four UFC fights.