O'Neal did not travel with the Cavaliers for their game Friday night against the Pacers. He is averaging 11.3 points and 6.9 rebounds. Cleveland coach Mike Brown didn't give a timetable for his return.
Indiana forward Troy Murphy will play after missing six games with a bruised lower back.
The Pacers announced Friday that guard Travis Diener had surgery on the big toe on his left foot and is expected to miss at least four weeks.