Westbrook started and scored 16 points with two assists and five rebounds in 24 minutes after missing 27 games since having a procedure on Dec. 27 to deal with swelling in his injured right knee -- the third operation on the knee in nine months.
Westbrook had made it through a full practice Wednesday for the first time since his most recent surgery, and coach Scott Brooks had said he looked good.
Westbrook, a three-time NBA All-Star, tore the lateral meniscus in the knee during the playoffs last April. He underwent an operation after that injury and had another procedure on Oct. 1 to remove a loose stitch.
Oklahoma City went 20-7 after Westbrook's latest setback.