Curry did not take part in the morning shootaround Monday, getting treatment instead, and his status will be determined before the game.
"I'm preparing as if he's not going to play because you don't want to be surprised at a game-time decision," teammate Klay Thompson said. "So we're preparing as if he's not going to be out there."
Curry injured his right ankle when he landed awkwardly late in the first half of a 104-78 win over Houston in the series opener Saturday. He tried to come back in the second half before being quickly pulled by coach Steve Kerr.
Golden State already beat the Rockets once this season without Curry, winning 114-110 in Houston on Dec. 31. Thompson picked up much of the scoring load with 38 points that game, and Andre Iguodala added 20.
Thompson said it will take more than just him to replace Curry's league-leading 30.1 points per game and everything else he offers.
"Obviously 30 points out of the lineup, a lot of playmaking, a lot of easy buckets," Thompson said. "We just have to do it in a more meticulous way as far as moving the ball, being more patient. Without Steph in the lineup, we don't have those easy looks in transition he usually gives us. We just got to do it even more as a team now and rely heavily on our defense and get out on transition."
If Curry can't play, Shaun Livingston will start in his place. Livingston averaged 6.3 points and 3.0 assists per game this season.