Jackson was helped off the court after injuring his ankle midway through the third quarter Tuesday night vs. the Pacers. He did not return.
The 27-year-old is averaging 14.6 points and 5.5 assists per game.
Jackson was limited to 52 games last season, largely due to a knee injury.
The Pistons play Thursday night at Orlando and will likely start Ish Smith in place of Jackson.
Information from The Associated Press was used in this report.