"I tried to give it a go and I just couldn't move right," Hill told ESPN's Dave McMenamin.
Hill also sat out Game 4, but the Cavs were able to hold on to a second-half lead and beat the Pacers to even the series. Hill has been bothered by a bad back since he was hit from behind by Indiana's Trevor Booker in the series opener.
Hill told ESPN that he has felt an improvement with his back since Game 4.
Jose Calderon will start in place of Hill, who came to the Cavs in February via trade from Sacramento. Hill, 31, is averaging 8.7 points and 1.7 assists in the postseason.
Cavs coach Tyronn Lue did not provide any details on Hill's injury or his status going forward in the series. Hill received four injections in an attempt to play in Game 4.
Calderon has been in and out of Cleveland's lineup all season. He's averaging 3.3 points and 14 minutes in the series.
The Associated Press contributed to this story.