It is the first game Wade has missed this season -- his 16th and final campaign in the NBA. He is averaging 14.3 points on 45 percent shooting in nine games, all of them as a reserve.
The Heat also were without starting point guard Goran Dragic, due to a sore right knee, and Dion Waiters and James Johnson remain out for the foreseeable future as they recover from surgeries. Heat center Hassan Whiteside returned to the starting lineup after sitting Monday with knee pain.
The Spurs not only got point guard Derrick White (heel) back for the first time this season, but he was in the starting lineup. However, Pau Gasol was out with a sore right foot, and Rudy Gay was sidelined with a right heel problem.