Durant added eight rebounds in Istanbul, the city where he was MVP of the world basketball championship in 2010 when he led the U.S. to the gold medal.
"I think we did a good job of responding after the first quarter," Durant said, according to The Oklahoman. "We gave up 28 points (in the first quarter) but we did a great job the last three quarters on defense. That's really what we tried to preach, is making sure our defense is locked in every possession. Guys off the bench did a really, really good job of setting the tone and we followed their lead from there."
Serge Ibaka added 15 points, six rebounds and four blocked shots for the Thunder. Reggie Jackson, starting at point guard while All-Star Russell Westbrook recovers from knee surgery, had nine points and five assists.
Bojan Bogdanovic, a former Nets draft pick, made four 3-pointers and scored 19 points for Fenerbahce Ulker.
Thunder center Kendrick Perkins dislocated the ring finger on his left hand while battling for a rebound late in the second quarter.
Perkins did not return to the contest, and Thunder coach Scott Brooks did not indicate whether the 11-year veteran would miss any time due to the injury.
Rookie Steven Adams, the 12th overall pick in this year's draft, replaced Perkins as Oklahoma City's primary center in the second half. The 7-footer finished with seven points and six rebounds.
Jeremy Lamb, who appeared in just 23 games last season, played a game-high 31 minutes Saturday, scoring nine points and handing out four assists.
The Thunder move to Manchester, England, to play the Philadelphia 76ers on Tuesday.
Information from The Associated Press was used in this report.