"We didn't know Dwyane wasn't playing until about 45 minutes before the game," Heat coach Erik Spoelstra said. "Dr. [Harlan] Selesnick said he wants to make sure we get an MRI on his wrist to make sure there isn't any significant damage. We'll do that tomorrow morning. Once we find out the results, hopefully [Wade] can have a clear head and play through it."
Wade suffered the sprain when he fell in the second half of the Heat's 93-88 loss at New York on Thursday night. He is listed as day to day.
"He wanted to play through this tonight," Spoelstra said.
After being examined pregame by team medical personnel, Wade was ruled out of action for precautionary reasons. He missed the Heat's last home game six nights ago with a migraine.
Wade has been battling migraines over the past week. He missed the Heat's victory over Toronto on Jan. 22 and wore tinted glasses in Heat's loss at New York on Thursday.
The team said Wade's wrist got stiffer as the game drew closer. The announcement that he would not play was made about 15 minutes before tipoff. Not only did Miami already have him listed in the starting lineup, but Heat coach Erik Spoelstra said only that Wade's wrist was "a little bit sore."
Miami had a brief scare in the second quarter when LeBron James stumbled to the court -- and caught a knee in the head on the way down, courtesy of teammate Joel Anthony. James also appeared to twist his left ankle on the play, but after taking a 20-second timeout to recover, remained in the game.
The Heat are already without Chris Bosh, who is recovering from a high ankle sprain. Spoelstra did not rule Bosh out for Sunday's game at Oklahoma City.
Including Friday, Bosh has now missed four games since getting hurt after Chicago's Omer Asik rolled into his leg in a game at the Bulls on Jan. 15. He was able to take part in what Spoelstra said was "an extensive workout" before the Pistons game.
"We've said he's our crutch," Spoelstra said. "Our game looks a lot different in terms of ball movement and getting people involved when Chris plays."
Mike Miller started Friday in Wade's place. James again started at power forward in Bosh's absence.
Information from The Associated Press was used in this report.