Heat coach Erik Spoelstra said Wade is "hopeful" for Wednesday's key home game against the Boston Celtics. Wade struggled shooting and scored just 15 points in the Heat's 91-72 loss.
"We want to be very smart about it right now and take the next 24 hours and do some treatment," Spoelstra said. "Because of the schedule and everything -- we're not weighing opponents or anything like that -- but I think we'll see some significant progress in the next 24 hours."
The Heat were vague on details of when Wade got hurt and downplayed the severity. He also took part in the team's practice on Monday and shootaround on Tuesday morning, suggesting the team may be trying to get Wade some rest.
Wade has shown signs of wear recently after the team played six games in nine days, with five games on the road.
"You have to weigh a lot of things right now," Spoelstra said. "That's the reality of the schedule this year."
Tuesday marked Wade's 10th missed game this season due to injury. The Heat went 8-1 earlier this season in two stints without Wade.
Information from The Associated Press was used in this report.