The Wildcats (12-7, 7-1 Big Sky) pulled away early in the second half with a 21-4 run capped by Harding's pair of free throws to make it 72-51 with 9:13 left. The Bengals (3-17, 1-7) got the deficit no lower than 16 from there.
Kyndahl Hill added 12 points for Weber State which won its 10th of the last 11 and stayed in first place in the conference.
The Wildcats made 30 of 55 shots, 13 of 23 from 3-point range, and 23 of 26 from the foul line. Senglin was 4 of 8 from 3-point range and Harding was 3 of 4.
Allonzo Trier made eight of nine shots, including all three 3-point attempts, for 28 points and No. 3 Arizona coasted to its third straight victory, 91-59 over Cal State-Bakersfield on Thursday night.
Xavier has a big second half to top the home team Wisconsin 80-70.
Travis Munnings and Marvin Jean-Pierre scored 19 points apiece to help Louisiana-Monroe beat Southeastern Louisiana 86-75 on Thursday night.