Bolden, who ranked third in the Big Ten in rushing average last fall at 77.9 yards per game, suffered a noncontact injury to his right knee, the same knee in which he suffered a torn ACL as a high school senior.
Hope said he didn't know the extent of Bolden's injury Friday but told reporters the coaching staff is preparing for the chance Bolden will miss the 2010 season.
"If he's healthy and ready to go, we would love to have him," Hope told The (Lafayette) Journal and Courier. "But we're not going to put our eggs all in one basket. We have to get some other guys ready to go."
Injuries have plagued Purdue this spring, and the team is without 10 starters, including defensive end Ryan Kerrigan. Purdue announced Friday that because of the injuries, it will postpone practices Saturday and Monday and make them up following the spring game on April 19 and April 21.
The Boilermakers practice next on Wednesday.
Adam Rittenberg covers Big Ten football for ESPN.com. He can be reached at firstname.lastname@example.org.