The Spartans will host the Broncos in the 2012 opener on Friday, Aug. 31, which is part of a single-game contract. ESPN will televise the game.
Michigan State and Boise State also agreed to a home-and-home series to be played in 2022 and 2023.
Michigan State will travel to Boise State on Sept. 17, 2022, and host the Broncos on Sept. 16, 2023.
"We're extremely excited about this special opportunity to kick off the 2012 season with a nationally televised game against Boise State, the nation's winningest football program since 1997," Michigan State athletic director Mark Hollis said in a prepared statement. "As we try an innovative concept with a Friday night Labor Day weekend game, we couldn't pull something like this off without campus-wide cooperation."
Michigan State recently announced a home-and-home series with Miami and also will play both Alabama and West Virginia in future years. The Spartans have extended their rivalry series with Notre Dame through 2031 with two-year breaks in 2014-15, 2020-21 and 2026-27.
Adam Rittenberg covers Big Ten football for ESPN.com. He can be reached at firstname.lastname@example.org