McGloin will make his second career start, although coach Joe Paterno said freshman Rob Bolden might play, too. The former walk-on relieved Bolden last week against Northwestern and led Penn State on five consecutive scoring drives as the Nittany Lions rallied for a 35-21 victory.
Paterno had planned to play both quarterbacks against Northwestern.
Saturday will be McGloin's second career start. He relieved Bolden on Oct. 23 against Minnesota after the freshman suffered an apparent concussion and started the next week against Michigan.
McGloin has completed 35 of 57 pass attempts for 475 yards, five touchdowns and no interceptions in his last two games.
Adam Rittenberg covers Big Ten football for ESPN.com. He can be reached at firstname.lastname@example.org.