Bolen ran for 67 yards and Victor Anderson ran for 161 yards, including an 88-yard touchdown.
The Blue Raiders (2-5) took advantage of two first-quarter interceptions by Cantwell. Jeremy Kelley returned the first one for a 14-yard touchdown and less than three minutes later, an interception by Ivon Hickmon set up a 39-yard pass from wide receiver Patrick Honeycutt to Phillip Tanner to give the Blue Raiders a 14-0 lead.
But Bolen ran for 1-yard scores in the third and fourth quarter, and Cantwell's 1-yard touchdown pass to Johnnie Burns capped a second half in which Louisville outscored the Blue Raiders 28-6.
Early in the game, it looked like it would be another like last season's shootout when Louisville won 58-42. Though the Cardinals won that game, the Blue Raiders ran up 555 yards of offense, compared to 306 on Saturday. The Cardinals had 391 offensive yards.
With the Blue Raiders up 14-0, Bolen scored his first touchdown on a three-yard run up the middle.
The Cardinals forced the Blue Raiders to punt on their next series but found themselves pinned down on their own 12. Anderson's 88-yard run up the middle, the fourth longest in Louisville history, on second down tied the score at 14-14. The Blue Raiders went into half time with a 17-14 lead after Alan Gendreau's 42-yard score.
Louisville's defense, ranked 30th in the nation going into the game, forced Middle Tennessee to punt on seven of eight drives after the Blue Raiders' second touchdown, and held the Blue Raiders to 93 yards of offense in the second half.
Middle Tennessee switched back and forth between quarterbacks, using the more mobile Dwight Dasher on several possessions. Dasher finished with 31 rushing yards and 10 passing yards. Phillip Tanner led the Blue Raiders in rushing with 46 yards on 13 carries.
Louisville used its rushing game to control the clock in the second half, holding the ball for 19:33, to Middle Tennessee's 10:27. Bolen scored two more touchdowns of a yard each in the second half and Johnny Patrick recovered a blocked punt in the end zone to put the game out of reach for good.
Cantwell added an insurance touchdown pass to Johnnie Burns with 2:30 to play.
Vanderbilt lineman Rutger Reitmaier, who sat out the 2017 season after transferring from Oregon, has received an NCAA waiver and can play this fall.
College football may still be a few months away, but it's never too early to get to know the players destined for highlight-worthy moments this fall.
The University of Maryland has hired longtime collegiate athletic trainer and sports medicine consultant Dr. Rod Walters to conduct a review into the death of offensive lineman Jordan McNair.
Wake Forest has added two graduate transfer kickers: Darren Ford from Hope College, and Eric Osteen, who had been serving with the Army since graduating from West Point in 2013.
Notre Dame linebacker Te'von Coney has pleaded guilty to marijuana possession from an incident two years ago. Coach Brian Kelly said Coney would be back if he "takes care" of the court case.
Tennessee has boosted its offensive line by adding Alabama graduate transfer Brandon Kennedy.