Gamble had 15 carries for 163 yards and a 75-yard touchdown run. Smith ran 15 times for 105 yards and two scores, the second from 50 yards out.
Iona (3-8) outgained Bryant 389-377, but had 136 yards in penalties. Warren Smith was 30-for-52 for 256 yards.
Arkansas State's Tajhea Chambers recovers a Georgia State fumble for a 34-yard touchdown to put the Red Wolves up 34-7.
Arkansas State RB Marcel Murray spins out of tackle and flies down the sideline for a 64-yard run that sets up the Red Wolves for another touchdown.
Arkansas State's Jonathan Adams beats his man and high points a pass from QB Justice Hansen for a 35-yard touchdown.
Arkansas State's Warren Wand catches the ball and then erupts for a 91-yard kickoff return which sets the Red Wolves up for another score.
Georgia State QB Dan Ellington hits Tamir Jones on the slant, who scores a 36-yard touchdown to even the score at 7-7.
QB Justice Hansen finds a wide-open Javonis Issac for a 30-yard touchdown to put Arkansas State on the board.