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USC will need to defeat Stanford to keep the momentum it built in 2016 rolling, but the Trojans must not look past a late-September road game at Wazzu.
The Sooners want to avoid another shootout with Texas Tech, while an October matchup with Kansas State will be difficult.
A rebuilding Syracuse squad faces the toughest schedule of any ACC team and will likely be considered the underdog in the majority of their games.
Vanderbilt looks to take more steps forward, but the Commodores will have to make it through a gauntlet of a midseason schedule.
Clemson may have the talent to replace its departing stars on offense, but its rugged September schedule will surely pose a challenge.
Florida State's quest to return to the College Football Playoff will begin with the season-opening matchup against Alabama.