Saturday's upsets didn't just affect the top-ranked teams in the country.
While No. 1 Duke and second-ranked Tennessee both lost Saturday, the No. 1 seeds in Conference USA, the Northeast Conference and the Patriot League also were each eliminated from their league tournaments -- before even reaching the championship game.
And in the Southern Conference, second-seeded Chattanooga toppled No. 1 seed Western Carolina, which had swept the Lady Mocs in the regular season, for the league's automatic bid.
The most surprising upsets among the mid-majors involved No. 8 seeds upsetting the No. 1. That happened in both the Patriot League -- where Colgate scored just its sixth win of the season (the Raiders are 6-24) with a 69-62 victory over 1-seed Bucknell -- and NEC -- where St. Francis (N.Y.) toppled No. 1 Long Island 61-51. In both cases, the No. 1 seeds swept the regular-season series. Bucknell had beaten Colgate by a combined 58 points.
In the C-USA, Tulane lost to Rice 64-52. They split the regular-season series, though the Green Wave lost just three league games this season.
Some top seeds cruised, of course. Ninth-ranked George Washington, the Atlantic 10's No. 1 seed, routed Dayton 61-45 to advance to Sunday's semifinals. Stanford beat Arizona 65-55. Marist also cruised past Siena 71-55 in the MAAC. Oakland (Mich.) obliterated Centenary 82-51 in the Mid-Continent's first round. And top-seeded Southeast Missouri edged Murray State for the Ohio Valley's automatic bid.
Duke was the nation's only unbeaten team in men's and women's basketball before falling to No. 25 NC State 70-65 in the ACC semifinals. The Blue Devils (30-1) have notched an NCAA-record seven straight seasons with at least 30 wins.
Tennessee, which went undefeated in the SEC regular season, lost 63-54 to fourth-seeded LSU.
Through Saturday, three teams had secured berths in the NCAA Tournament. In addition to Southeast Missouri and Chattanooga, Harvard also clinched a bid on Friday, winning the Ivy League regular-season title.