Chandler missed Tuesday's win against the Washington Wizards, thanks to lingering soreness in his neck. The All-Star center missed 10 games last month with a bulging disk in his neck.
Martin suffered what Knicks coach Mike Woodson called a "severe" left ankle sprain early in the fourth quarter Tuesday. The Knicks said X-rays on Martin's ankle were negative. He had missed the previous two games with a sore left knee.
Neither Chandler nor Martin flew to Chicago with the team on Wednesday, so they will miss both road games on the Knicks' trip: Thursday against the Bulls and Friday at Cleveland.
Martin and Chandler's statuses for Sunday's home game against Indiana are unclear at this point.
New York has won 13 straight games, the third-longest winning streak in franchise history. The Knicks clinched their first division title in 19 years on Tuesday and enter play Wednesday 2½ games ahead of the Indiana Pacers for second place in the Eastern Conference.
However, the Knicks are 0-3 this season against the Bulls.
Chandler returned to the court last week but told Woodson that he needed to rest on Tuesday after feeling soreness following Sunday's win in Oklahoma City.
"He's sore, so if he tells me he needs some rest, then I've got to listen and rest him and get him ready for the next game if he's capable of playing," Woodson said Tuesday.
Marcus Camby is also listed as doubtful for the game because of a left plantar fascia ailment. If Camby can't play, the Knicks will be woefully undersized against Chicago.
Ian Begley is a regular contributor to ESPNNewYork.com.