He immediately left the field and was replaced by Drew Stanton, who started the second half. Hill spent part of the second half on the sideline with his arm in a sling.
"He wanted to go back in but he had a hard time, no matter how we splinted it, trying to take a snap," Lions coach Jim Schwartz said.
The Lions also lost linebacker Zack Follett, who fell motionless to the field after a helmet-to-helmet collision during a kickoff return.
Follett was tackled by Giants defensive end Jason Pierre-Paul, who lowered his head for a helmet-to-helmet hit which caused Follett's neck to bend back. The Lions came off the bench to watch as Follett was secured to the brace. Giants fans gave him a standing ovation as he exited the stadium.
"I knew right away he was hurt," Pierre-Paul said.
Follett was strapped to a backboard, carted off the field and taken to a nearby hospital. The Lions said Follett is conscious and has feeling and movement in his extremities, but he was not on the team's flight back to Detroit. Additional tests on Follett were negative and he posted on Twitter, "Thank you and much love to all you showing your support. I'm ok. Thank God."
ESPNNewYork.com's Jane McManus and The Associated Press contributed to this report.