Both are listed as questionable, but previously have said that if they made the flight to Arizona, they would play.
Long snapper Zak DeOssie, who did not practice Thursday and Friday because of a back injury, also will play.
If Umenyiora's knee does not swell up, he is expected to make his season debut. He missed the first three games while recovering from arthroscopic knee surgery he had on Aug. 19. Umenyiora practiced on a limited basis all week before joining the Giants on their trip.
"It feels good," Umenyiora said of his knee Friday. "There's always going to be some sort of lingering issues or whatever. There's no swelling. It's good."
Tuck did not practice Wednesday or Thursday before going through a limited practice Friday because of a strained groin and pain in his neck. The defensive end has been battling the neck issue since the preseason.
"Well, if I get on that plane going to Arizona, I am playing," Tuck said Thursday. "Honestly, they are trying to buy some time here. The less I can do, the less it will be aggravated. We are just buying time."
And that bodes well for Coughlin, who is expected to have his full arsenal of defensive ends -- Tuck, Umenyiora and Jason Pierre-Paul -- for the first time this season.
Pierre-Paul, who has 4½ sacks starting in place of Umenyiora, said Umenyiora will start when he returns to action.
Ohm Youngmisuk covers the Giants for ESPNNewYork.com.