Bradshaw suffered a cracked bone in his foot last Sunday against Miami, it was revealed Thursday.
A source told ESPN NFL Insider Adam Schefter that the injury is not considered serious and that Bradshaw "should play Sunday" against the Patriots.
Coach Tom Coughlin confirmed on Friday that Bradshaw will forgo surgery, attempting to play through the foot injury, just as he did in 2009. That season, Bradshaw played nine games with broken bones in both feet.
If Bradshaw can't play, embattled running back Brandon Jacobs likely will start in his place.
Jacobs was booed at home Sunday after running for just 10 yards on four carries. He also complained about his role late last week.
Nicks, the Giants' top wide receiver, suffered a hamstring injury last Sunday against Miami and hasn't practiced all week.
"He feels a little better today than he did yesterday and so we'll see," Coughlin said.
The receiver said Thursday that he wouldn't risk further injury to suit up against the Patriots.
"I don't think it is nothing crazy like it will (keep me out for) two, three or four weeks," Nicks said Thursday. "It is a matter of me not wanting it to be there so I have to be cautious about it and take care of it."
Also on the injury front, defensive lineman Jason Pierre-Paul may have suffered a concussion on Thursday as the result of a helmet-to-helmet collision in practice. After experiencing headaches, Pierre-Paul went through concussion testing on Friday.
"I didn't think anything of it, then all of a sudden he was off to the side and he didn't feel real good. So they shut him right down," Coughlin said.
The result of testing wasn't immediately available. The defensive end is listed as questionable for Sunday's game against New England.
The Giants lead the NFL in sacks and were hoping to put the pressure on Brady in New England, where the Patriots have won 20 consecutive regular season games. Pierre-Paul's absence may compromise that.
"If he can't play, the next man is going to have to step up," defensive lineman Chris Canty said.
On the other side of the Giants' line, center David Baas is doubtful with a knee injury that has sidelined him for the week. He said Friday that he's hopeful of playing. If he can't, Kevin Boothe may start at center in his place.
Cornerback Prince Amukamara (foot) will make the trip to New England, but Coughlin will wait until game day to see if he will be on the active roster. Amukamara is officially listed as questionable.
Tackle Stacy Andrews has been ruled out of Sunday's game because of a back injury.
Lastly, fullback Henry Hynoski is questionable with a neck injury. Linebacker Michael Boley (knee), wideout Mario Manningham (illness), tight end Bear Pascoe (finger), Justin Tuck (groin) and Osi Umenyiora (knee/shoulder) are all probable.
Ian Begley is a regular contributor to ESPNNewYork.com.