Neal injured an ankle in the opening game of the first-round series. Orpik has been sidelined for five games because of an undisclosed injury.
The Penguins have done just fine without both players, winning two of the first three games.
Neal, who didn't record a point in the one game he has played in these playoffs, took line rushes with Evgeni Malkin and Jarome Iginla during pregame warmups. Neal had 21 goals and 36 points in 40 regular-season games.
Orpik was a plus-17 during the regular season.
Information from The Associated Press was used in this report.