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Answering Week 1's biggest fantasy football questions

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Berry lists best fantasy free agents (1:05)

Matthew Berry lists the best QBs, RBs, WRs and TEs still available in at least 50 percent of leagues, including Eli Manning and Jamaal Charles. (1:05)

Need some help setting your lineup to open the season? NFL Nation reporters answer the biggest fantasy questions -- provided by ESPN fantasy football analyst Mike Clay -- across the league for Week 1.

AFC East | AFC North | AFC South | AFC West
NFC East | NFC North | NFC South | NFC West


AFC EAST

Buffalo Bills

Who will lead the Bills in targets against the Jets?

Jordan Matthews said in the locker room Thursday that he will be "full go" Sunday despite missing all three of his preseason games since joining the Bills with a fractured sternum. Even if Matthews plays a normal snap load, I have a hard time imagining he and Tyrod Taylor would be up to speed with their timing. The more likely candidate to lead the Bills in targets is TE Charles Clay, who now has worked with Taylor longer than any other Bills pass-catcher (since 2015). -- Mike Rodak

Miami Dolphins

Do you expect DeVante Parker to be prioritized ahead of Jarvis Landry as Jay Cutler's go-to target this season?