After the Patriots' 41-7 win, coach Bill Belichick said that Harrison's injury "doesn't look too good," but he said that the team wouldn't say more until Tuesday.
Patriots running back Sammy Morris also hurt his knee in the first half after rushing for a career-high 138 yards and was not expected to return.
Boss and Champ Bailey, brothers on the Broncos' starting defense, suffered injuries in the first half that were expected to sideline them for the rest of the game. Linebacker Boss Bailey hurt his left knee before cornerback Champ Bailey suffered a groin injury.
The Broncos also lost quarterback Jay Cutler with a hand injury for their final possession of the first half, when he was replaced by Patrick Ramsey. Cutler appeared to be hurt on Denver's first offensive play when his hand hit the helmet of nose tackle Vince Wilfork.
Cutler returned for the Broncos' first series of the second half.
Information from The Associated Press was used in this report.