The Colts, however, issued a statement Friday afternoon to "provide accuracy with respect to medical facts" which said that the second procedure had nothing to do with the infection.
"Peyton Manning developed swelling in his left pre-patella bursa in late February," the Colts said in a statement released in conjunction with the club's physicians. "The swollen bursa was treated conservatively beginning in February with drainage and anti-inflammatory medication.
"The first signs of infection occurred while he was in New Orleans in July. It should be noted that infection developed prior to any surgery. Upon manifestation of the signs of infection, he immediately had surgery to remove the bursa sac. Concurrently, he was treated aggressively with antibiotics, and the infection was eliminated.
"The second procedure [tacking of the skin to eliminate the bursal space] was designed to ensure the complete and swift resolution of the bursal problem. The procedure was successful.
"The second procedure was in no way, shape or form, related to the infection. The second procedure did not delay his rehabilitation or recovery materially."
Manning is the second high-profile NFL quarterback to make the news this week because of a severe infection in the knee. Tom Brady of the New England Patriots reportedly had additional, infection-clearing procedures done on his knee following the initial early October surgery to repair the medial collateral and anterior cruciate ligaments.
Cleveland tight end Kellen Winslow had a bout with a staph infection this month and was hospitalized for three days.
He missed the Browns' upset of the New York Giants on Oct. 13,
before returning for last week's game against the Redskins despite
Manning's initial surgery was in July, when the bursa sac in his left knee had to be operated on because of the staph infection, according to the Star.
ESPN's Chris Mortensen reported previously that the second procedure took place 17 days after the original surgery, further delaying Manning's progress in training camp.
Doctors were concerned about the fluid that had infected the bursa sac, which had been removed in the original operation.
The Star reported Friday that it was the same staph infection that forced the second procedure.
The Colts' statement also sought to clarify that Manning had a staph infection, but not methicillin-resistant Staphylococcus aureus (MRSA), a potentially dangerous type of staph bacteria that is resistant to certain antibiotics and may cause skin and other infections.
"It also should be noted emphatically that, at no time, did he have MRSA. It is clear from consultation with our physicians, including infectious disease specialists, that staph is a societal medical problem. There is no empirical evidence that indicates to our physicians there is a problem related to resistant staph [MRSA] with respect to the Indianapolis Colts."