Though coach Dick Jauron wouldn't say Monday how much time Reed might miss, it generally takes players two to three weeks to recuperate from such injuries, depending on their severity. Jauron also didn't indicate which ankle Reed hurt late in the second quarter of a 25-16 loss at Miami on Sunday.
Reed ranks second on the team with 26 catches for 288 yards. He is also second on the Bills, and tied for 16th in the AFC, with eight catches for 116 yards in third-down situations. Without Reed, the Bills will have to rely more on slot receiver Roscoe Parrish and rookie second-round pick James Hardy to play behind starter Lee Evans.
The Bills (5-2), in the midst of playing three straight games against AFC East rivals, host the New York Jets (4-3) on Sunday. Buffalo has lost two of three and now shares top spot in the division with New England, which it will face on Nov. 9.
Reserve guard Jason Whittle could not finish against the Dolphins after straining his left quadriceps. Jauron said it was too early to determine whether he will practice this week.
Whittle was starting in place of Brad Butler, who did not play against Miami because of a sprained left knee.