Browns coach Romeo Crennel said during his weekly news conference that the team is preparing to make an announcement on Jurevicius soon, and the coach hinted that it was "generally not good."
The Browns have until Tuesday to take Jurevicius off the physically-unable-to-perform list or deactivate him for the season. Jurevicius had routine knee surgery in the offseason but contracted a staph infection that set back his timetable to return.
"It's 99 percent sure that he is done for the season," the source said.
Browns tight end Kellen Winslow Jr. had a high-profile bout with staph two weeks ago that put Cleveland's issues with the infection to the forefront. Winslow was the sixth known Browns player to develop staph in the past few years.
Jurevicius' case has been relatively low-key. It is unknown if Jurevicius will retire or attempt a comeback next year. The 11-year veteran said this would be his final season, but he still has one year remaining on his contract.
For his career, Jurevicius has 323 catches for 4,119 yards and 29 touchdowns. He also won a Super Bowl in 2002 with the Tampa Bay Buccaneers.
James Walker covers the AFC North for ESPN.com.