Brandon Jacobs practiced, an early sign the big halfback would be back in the lineup this weekend for the NFC showdown against the Panthers.
Jacobs missed the game against Dallas last weekend after aggravating his left knee in a game against the Eagles the week before.
"This game is very important," said Jacobs, who has rushed for 1,002 yards and 12 touchdowns. "You have a good football team coming in here. We are the head honchos of the conference and this game means a lot to our team. I want to be out there to have better chances for our team to win. Whatever I can do to help us win, I'm all for that."
The winner will capture the NFC's No. 1 seed for the playoffs.
Jacobs said he pleaded with the team's trainers to play against Dallas and was turned down.
"I don't want to plead this week," he said. "There is no choice. I want to go. Whoever I have to talk to in order to get this verdict, that's what I'm going to do."
Fellow running back Derrick Ward (ankle), defensive tackle Fred Robbins (shoulder), receivers Sinorice Moss (calf) and Domenik Hixon (ankle-foot) and linebacker Gerris Wilkinson (knee) did not practice on Wednesday.
The Super Bowl champions made four roster moves, signing receiver Derek Hagan and linebacker Edmond Miles, while placing linebacker Jonathan Goff (hamstring) and running back Reuben Droughns (neck) on injured reserve.
Droughns injured his neck Sunday night in Dallas.
Hagan was released by Miami on Nov. 4. He caught 53 passes for 643 yards and three touchdowns in 2½ seasons, including three catches for 51 yards this season.
Goff, the team's fifth-round draft choice, played in only five games because of an assortment of injuries, the last being a hamstring.
Miles played 16 games for the Miami Dolphins in 2007, when he had a team-high 16 special teams tackles.