Manning extended his own NFL record for 4,000-yard passing seasons to nine, while Harrison moved into second on the NFL's career receptions list and Clark broke the franchise's long-standing single-season record for yards receiving by a tight end.
And they needed only about 23 minutes to complete the trifecta.
Manning entered the game needing 93 yards to hit 4,000, achieving it on a 55-yard touchdown play to Joseph Addai. The two-time league MVP left the game after the opening possession, finishing 7-of-7 for 95 yards with one TD and a perfect 158.3 rating. He has failed to hit 4,000 yards passing in only two of his 11 NFL seasons -- 1998, his rookie year, and 2005, when he threw only 14 passes in the final two games and finished with 3,747 yards.
Dan Marino ranks second all-time with six 4,000-yard seasons.
Harrison, the record-setting receiver, achieved another milestone midway through the second quarter. A short pass from Jim Sorgi gave Harrison his seventh reception of the game and 1,102 in his career. It moved him past Cris Carter for second all-time, leaving him behind only Jerry Rice, who holds the league record with 1,549.
Clark also had his moment in the spotlight.
He needed 41 yards to break the record set by Hall of Famer John Mackey in 1966. Clark accomplished that when he turned a short pass into a 23-yard gain on the second play of the second quarter. He left the game with six catches for 59 yards, giving him 848 yards, 19 more than Mackey's previous mark.