Cotchery, the team's leading receiver, was injured in practice three weeks ago. He played in the loss at Miami on Oct. 12, then sat out a loss to Buffalo and a win at Oakland Raiders.
Smith has also missed the last two games with a quadriceps injury, while Clowney has an injured ankle. Also questionable are defensive end Shaun Ellis (knee/ankle) and linebacker Bart Scott (knee). Coach Rex Ryan said Friday he expects them all to play.
Lito Sheppard is questionable with a right quadriceps injury and isn't expected to play.