Wide receiver Reggie Wayne (strained groin) and defensive end Dwight Freeney (knee) both took part in Friday's practice and are expected to play. Defensive tackle Eric Foster (shoulder) also practiced and should be available against the 49ers.
Freeney was hurt against St. Louis last Sunday but didn't really feel the effects of the injury until Monday morning.
"I'll be out there [Sunday]. My knee was a little stiff this week, but it has to be real serious for me [to miss a game]," he said. "I've got the swelling down now, so I should be all right."
"What we do with them is let Joe take as many of [rushing attempts] as he wants, and when he wants to come out of there, we relieve him at that time," coach Jim Caldwell said. "[Hart] is a possibility. He's been working in practice, and he's certainly ready to go."