It's the same knee Bush had surgery on last December to repair cartilage.
Bush is coming off one of his best games of the season in St. Louis last Sunday, when he gained 98 yards and scored two touchdowns on six rushes and a pair of receptions.
Saints coach Sean Payton says Bush has had some swelling in the knee and is getting some rest. Payton would not say what Bush's chance of playing are this Sunday in Tampa Bay.
Payton says he hopes Bush can practice Friday but that the team will be cautious about doing anything that could set him back.
Bush was not available for comment.