Otah tore the meniscus in his left knee Sunday against the New England Patriots and becomes the 10th player to be lost for the season.
General manager Marty Hurney says Otah will undergo surgery. His loss means Carolina will be without both starting tackles from the start of the season. Jordan Gross broke his leg last month.
Pat Yasinskas covers the NFC South for ESPN.com. Information from The Associated Press was used in this report.