Best has a Grade 2 turf toe injury and is considered day to day. He should be ready this week unless his pain is unbearable, a league source told ESPN NFL Insider Adam Schefter.
After five touchdowns and 268 yards from scrimmage in his first two NFL games, Best was limited to 26 yards rushing on seven attempts and two catches for 13 yards by the Vikings.
Coach Jim Schwartz said Best was also bothered by his toe in the season opener two weeks ago, but Best said this was a "totally new" injury.
"I got tackled on a pass I caught over the middle," Best said. "They wrapped me up and tackled me, and I got up and my toe wasn't feeling right."
Best was the 30th pick in the first round of the draft, a selection acquired from the Vikings in a draft-day trade.
Information from The Associated Press was used in this report.