Moreno, Denver's primary back, scored a touchdown in each of the Broncos' first two games this season, totaling 111 yards rushing on 39 carries.
Broncos linebacker Wesley Woodyard (hamstring) was ruled out by McDaniels earlier in the week. The coach has watched cornerback Andre' Goodman (quad) practice the past couple of days on a limited basis and expected that he will play.
Denver right tackle Ryan Harris (knee) also is expected to be back on the field in a starting role.
Information from ESPN.com senior NFL writer John Clayton and The Associated Press was used in this report.