Broncos coach Josh McDaniels made the announcement Friday.
Denver visits AFC North co-leader Baltimore (3-1) on Sunday, with the Broncos (2-2) trying to remain in the fray in the West.
Moreno had returned to the practice field Wednesday after missing last week's game because of the hamstring injury, but he was shut down Thursday and again Friday.
Larsen hasn't practiced all week and will miss his second consecutive game.
For Moreno, this will be the third game he will sit out because of the hamstring injury.
John Clayton is a senior NFL writer for ESPN.com.