Evans was hurt at the end of Jonathan Stupar's 35-yard reception in the second quarter. Evans was attempting to hold off a defender from catching Stupar from behind when he fell awkwardly while appearing to trip over his teammate's leg.
The 2004 first-round pick had a disappointing season, finishing with 37 catches for 578 yards and four touchdowns. It's his lowest reception total of his career, and seven less than his previous low of 44 catches in 2009.
The Bills also placed tight end Shawn Nelson on the Reserve, Non-Football Injury/Illness list because of migraine headaches.
Evans' streak of playing in 109 straight games, including 71 consecutive starts, will be snapped on Sunday when the Bills (3-10) play at the Miami Dolphins (7-6). The 71 total was the second-longest active streak for a receiver, behind Indianapolis' Reggie Wayne (126).
Evans' role this season had diminished with the emergence of Steve Johnson, who leads the team with 66 receptions for 874 yards and nine touchdowns. Those figures, clearly though, were helped by opposing defenses rotating coverages in Evans' direction.
"We'll see what [defenses] do, but obviously they will probably pay more attention to Stevie [Johnson] now, even though defenses have been paying attention to him pretty much since the first couple weeks," quarterback Ryan Fitzpatrick said. "We'll see how they adjust, and we're going to make some adjustments too, in terms of putting some guys in different spots. It will be interesting to see what happens on Sunday."
Evans is the second Buffalo receiver to have his season cut short because of an injury. Roscoe Parrish has been out since breaking his wrist in a loss to Chicago in Toronto on Nov. 7.
Shawn Nelson had missed the past three games after he began to suffer from migraines. He also missed the first four games after being suspended for violating the NFL's substance abuse policy. He had just three catches in five games.
The Bills also signed guard Colin Brown and tackle Erik Pears to the 53-man roster on Tuesday, and signed receiver Bobby Williams to the team's practice squad. Offensive lineman Marc Dile was released from the practice squad.